Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Cancer Drug Targets. 2024;24(12):1187-1194. doi: 10.2174/0115680096281059240103154836.
Obesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose tissue dysfunction, including insulin resistance, adipose tissue inflammation, adipocytokines secretion, and metabolic alterations. The pathogenesis of pancreatic cancer remains uncertain. However, there is evidence that dysregulation of local angiotensin II in adipose tissue that occurs in association with obesity is, in part, responsible for the initiation and progression of pancreatic cancer. Due to the role of local angiotensin II in the dysfunction of adipose tissue, angiotensin receptor blockers may be considered a new therapeutic strategy in the amelioration of the complications related to adipose tissue dysfunction and prevention of pancreatic cancer. This review aims to consider the biological roles of local angiotensin II and angiotensin II receptors in adipose tissue dysfunction to promote pancreatic cancer progression with a focus on adipose tissue inflammation and metabolic reprogramming.
肥胖和脂肪组织功能障碍是胰腺癌的重要危险因素。胰腺癌是全球最致命的癌症之一。肾素-血管紧张素系统（RAS）在许多组织中表达，包括脂肪组织。通过不同信号通路的激活，脂肪组织中血管紧张素 II 和血管紧张素 II 受体的失调导致脂肪组织功能障碍，包括胰岛素抵抗、脂肪组织炎症、脂肪细胞因子分泌和代谢改变。胰腺癌的发病机制仍不确定。然而，有证据表明，与肥胖相关的脂肪组织中局部血管紧张素 II 的失调部分是胰腺癌发生和发展的原因。由于局部血管紧张素 II 在脂肪组织功能障碍中的作用，血管紧张素受体阻滞剂可能被认为是改善与脂肪组织功能障碍相关的并发症和预防胰腺癌的一种新的治疗策略。本综述旨在考虑局部血管紧张素 II 和血管紧张素 II 受体在脂肪组织功能障碍中的生物学作用，以促进与脂肪组织炎症和代谢重编程相关的胰腺癌进展。
