Pignon Jean-Pierre, Auperin Anne, Borget Isabelle, Hill Catherine
Service de Biostatistique et d'Epidémiologie, Institut Gustave-Roussy, Villejuif cedex 95805, France.
Lung Cancer. 2009 Jul;65(1):9-12. doi: 10.1016/j.lungcan.2008.10.017. Epub 2008 Dec 6.
The paper contributes to the discussion on the usefulness of meta-analysis as compared to large scale trial. After reviewing the issues to consider when comparing the results of a meta-analysis and of a large trial, several examples, in particular in thoracic oncology, of complementary uses of meta-analysis and large trials are discussed. Three types of examples are presented: (a) trial designed to confirm the overall results of a meta-analysis; (b) trial designed to confirm an interaction between a covariate and the treatment effect detected in a meta-analysis; (c) trial designed to confirm an interaction between a treatment parameter and the treatment effect detected in a meta-analysis. In conclusion, well-conducted meta-analyses and large trials are complementary tools to evaluate new treatments.
与大规模试验相比，本文有助于对荟萃分析的效用展开讨论。在回顾了比较荟萃分析结果与大型试验结果时需要考虑的问题后，讨论了荟萃分析和大型试验互补使用的几个例子，特别是在胸科肿瘤学方面。给出了三种类型的例子：(a) 旨在确认荟萃分析总体结果的试验；(b) 旨在确认协变量与荟萃分析中检测到的治疗效果之间相互作用的试验；(c) 旨在确认治疗参数与荟萃分析中检测到的治疗效果之间相互作用的试验。总之，精心开展的荟萃分析和大型试验是评估新疗法的互补工具。
