Roshanpour Maryam, Ghasemi Mehdi, Riazi Kiarash, Rafiei-Tabatabaei Neda, Ghahremani Mohammad Hossein, Dehpour Ahmad Reza
Department of Pharmacology, School of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran.
Epilepsy Res. 2009 Feb;83(2-3):261-4. doi: 10.1016/j.eplepsyres.2008.10.011. Epub 2008 Dec 6.
The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression of tolerance were inhibited by ultra-low doses of naltrexone, suggesting the possible involvement of G(s)-coupled opioid receptors in the development of tolerance to the anticonvulsant effect of morphine.
本研究评估了在戊四氮诱导的阵挛性癫痫小鼠模型中对吗啡抗惊厥作用耐受性的发展，以及超低剂量的选择性阻断G(s)阿片受体的阿片受体拮抗剂纳曲酮是否能够预防所观察到的耐受性。结果表明，重复给药后吗啡的抗惊厥作用会产生耐受性。超低剂量的纳曲酮抑制了耐受性的发展和表达，提示G(s)偶联阿片受体可能参与了吗啡抗惊厥作用耐受性的发展。
