Bathelier E, Thomas L, Balme B, Coiffier B, Berger F, Ffrench M, Salles G, Dalle S
Service de dermatologie, université Claude-Bernard Lyon-1, hospices civils de Lyon, hôpital de l'Hôtel-Dieu, 69288 Lyon cedex 02, France.
Ann Dermatol Venereol. 2008 Nov;135(11):748-52. doi: 10.1016/j.annder.2008.07.057. Epub 2008 Sep 17.
No histological or clinical criteria allow distinction between primary cutaneous marginal zone B-cell lymphoma (MZL) and secondary cutaneous forms of systemic marginal zone B-cell lymphoma. Consequently, staging alone can indicate the origin of lymphoma. Lymphoma is considered as primary cutaneous only if no other extracutaneous sites are found. We studied the histological appearance of 49 cutaneous lymphomas in order to find distinctive criteria indicative of an extracutaneous origin.
This was a retrospective descriptive study of histological appearance for 49 patients with cutaneous marginal lymphoma: 29 cases of the primary form and 20 cases with extracutaneous involvement.
Comparison of histological criteria did not reveal any differences between the primary cutaneous form and others forms. No prognostic criteria for relapse were found.
A cutaneous tropism of primary MZL suggested the hypothesis of specific cutaneous receptors on B-cells that could have led to different histological appearances depending on the origin of the lymphoma. However, our study did not confirm this hypothesis.
目前尚无组织学或临床标准可用于区分原发性皮肤边缘区B细胞淋巴瘤（MZL）与系统性边缘区B细胞淋巴瘤的继发性皮肤表现形式。因此，仅靠分期就能提示淋巴瘤的起源。只有在未发现其他皮肤外部位时，淋巴瘤才被视为原发性皮肤淋巴瘤。我们研究了49例皮肤淋巴瘤的组织学表现，以寻找提示皮肤外起源的独特标准。
这是一项对49例皮肤边缘淋巴瘤患者组织学表现的回顾性描述性研究：29例原发性病例和20例有皮肤外受累的病例。
组织学标准的比较未发现原发性皮肤型与其他类型之间存在任何差异。未发现复发的预后标准。
原发性MZL的皮肤嗜性提示了B细胞上存在特定皮肤受体的假说，这可能导致根据淋巴瘤的起源出现不同的组织学表现。然而，我们的研究并未证实这一假说。
