Allingham R Rand, Liu Yutao, Rhee Douglas J
Duke University Eye Center, Duke University, Durham, NC 27710, USA.
Exp Eye Res. 2009 Apr;88(4):837-44. doi: 10.1016/j.exer.2008.11.003. Epub 2008 Nov 14.
Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease.
青光眼是全球不可逆性失明的主要原因。原发性开角型青光眼（POAG）作为最常见的青光眼类型，是一种复杂的遗传性疾病，在美国影响着超过200万人。越来越明显的是，许多遗传和环境因素都可能导致这种表型。关于POAG，已经报道了一些染色体和基因关联。这篇综述探讨了目前对潜在遗传结构的了解、有待学习的内容，以及这可能如何影响我们对这种主要致盲疾病的医疗管理。
