Patel Satin S, Carrick Kelley S, Carr Bruce R
Departments of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
Fertil Steril. 2009 Mar;91(3):933.e13-5. doi: 10.1016/j.fertnstert.2008.10.038. Epub 2008 Dec 4.
To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.
Case report.
University medical center.
PATIENT(S): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.
INTERVENTION(S): Exploratory laparotomy with full staging.
MAIN OUTCOME MEASURE(S): Surgical findings and histopathologic observations are included in this report.
RESULT(S): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery.
CONCLUSION(S): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.
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