Virilization persists in a woman with an androgen-secreting granulosa cell tumor.

OBJECTIVE

To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.

DESIGN

Case report.

SETTING

University medical center.

PATIENT(S): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.

INTERVENTION(S): Exploratory laparotomy with full staging.

MAIN OUTCOME MEASURE(S): Surgical findings and histopathologic observations are included in this report.

RESULT(S): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery.

CONCLUSION(S): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.