Kumar Anish, Menon Shobhana Karuveettil
Department of Chemistry, School of Sciences, Gujarat University, Navrangpura, Ahmedabad 380009, Gujarat, India.
Eur J Med Chem. 2009 May;44(5):2178-83. doi: 10.1016/j.ejmech.2008.10.036. Epub 2008 Nov 5.
A series of novel fullerene derivatives bearing s-triazine moiety have been synthesized by adopting 1,3 dipolar cycloaddition reaction of C(60) and azomethine ylides generated from the corresponding Schiff bases of 2,4,6 trisubstituted s-triazine. All the compounds synthesized were characterized by elemental analysis, FT-IR, (1)H NMR, (13)C NMR and FAB-MS. The compounds were then screened for their antibacterial activity against both gram-positive (Staphylococcus aureus, Bacillus subtilis, Bacillus pumilis) and gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria by disc diffusion method. All the compounds were found to be active against these strains at very low concentration and were comparable to standard drug ciprofloxacin.
通过2,4,6-三取代均三嗪相应席夫碱生成的甲亚胺叶立德与C(60)进行1,3-偶极环加成反应，合成了一系列带有均三嗪部分的新型富勒烯衍生物。所有合成的化合物均通过元素分析、傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（¹H NMR）、核磁共振碳谱（¹³C NMR）和快原子轰击质谱（FAB-MS）进行了表征。然后采用纸片扩散法，对这些化合物针对革兰氏阳性菌（金黄色葡萄球菌、枯草芽孢杆菌、短小芽孢杆菌）和革兰氏阴性菌（大肠杆菌、铜绿假单胞菌和肺炎克雷伯菌）的抗菌活性进行了筛选。结果发现，所有化合物在极低浓度下对这些菌株均具有活性，且与标准药物环丙沙星相当。
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