Obinata Hideru, Izumi Takashi
Department of Biochemistry, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):66-72. doi: 10.1016/j.prostaglandins.2008.11.002. Epub 2008 Nov 21.
G2A was identified as a G protein-coupled receptor that can be induced by different classes of DNA-damaging agents and block cell cycle progression in lymphocytes. We recently reported that G2A functions as a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids. When ectopically expressed in CHO cells, G2A mediates intracellular signaling events such as intracellular calcium mobilization and JNK activation in response to oxidized free fatty acids. In human epidermal keratinocytes, G2A mediates the secretion of cytokines including interleukin-6 and -8, and blocks cell cycle progression at the G1 phase in response to ligands. G2A might function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation.
G2A被鉴定为一种G蛋白偶联受体，可被不同类型的DNA损伤剂诱导，并阻断淋巴细胞的细胞周期进程。我们最近报道，G2A作为源自亚油酸和花生四烯酸的氧化游离脂肪酸的受体发挥作用。当在CHO细胞中异位表达时，G2A介导细胞内信号转导事件，如响应氧化游离脂肪酸的细胞内钙动员和JNK激活。在人表皮角质形成细胞中，G2A介导包括白细胞介素-6和-8在内的细胞因子分泌，并在响应配体时在G1期阻断细胞周期进程。G2A可能作为一种传感器，监测氧化状态并介导适当的细胞反应，如旁分泌信号的分泌和增殖的减弱。
