葡萄糖基芳基硫代氨基脲和葡萄糖基缩氨基硫脲衍生物作为抗氧化剂和抗血脂异常药物的合成与评价
Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents.
作者信息
Ghosh Samir, Misra Anup Kumar, Bhatia Gitika, Khan M M, Khanna A K
机构信息
Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
出版信息
Bioorg Med Chem Lett. 2009 Jan 15;19(2):386-9. doi: 10.1016/j.bmcl.2008.11.070. Epub 2008 Nov 24.
A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity.
一系列N-过氧乙酰基葡糖基芳基硫代氨基脲和硫代腙衍生物已被合成，并对其体内抗血脂异常活性和体外抗氧化活性进行了评估。在测试的16种化合物中，3种化合物表现出强效抗血脂异常活性，6种化合物表现出强效抗氧化和清除氧自由基活性。
Zotero 插件