Marhefka Joie N, Velankar Sachin S, Chapman Toby M, Kameneva Marina V
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Biorheology. 2008;45(5):599-609.
Natural and synthetic soluble drag reducing polymers (DRP) have been shown to produce beneficial effects on blood circulation in various animal models and may represent a novel bioengineering way to treat cardiovascular disorders. These polymers are known to degrade when subjected to high shear stresses which could be a part of the process of their elimination from the vascular system. However, the relative rate of their degradation was not known especially in the presence of blood cells or particles. The hydrodynamic tests in this study demonstrated that DRP mechanical degradation was significantly increased by the presence of red blood cells (RBC) and even more so by the presence of rigid particles of similar size. Degradation rates increased with an increase in RBC or particle concentration. The natural DRP (derived from aloe) was shown to be much more resistant to flow-induced degradation than polyethylene oxide in the presence or absence of RBC.
天然和合成的可溶性减阻聚合物（DRP）已被证明在各种动物模型中对血液循环产生有益影响，可能代表一种治疗心血管疾病的新型生物工程方法。已知这些聚合物在受到高剪切应力时会降解，这可能是它们从血管系统中清除过程的一部分。然而，它们的相对降解速率尚不清楚，尤其是在存在血细胞或颗粒的情况下。本研究中的流体动力学测试表明，红细胞（RBC）的存在会显著增加DRP的机械降解，而类似大小的刚性颗粒的存在则会使降解更明显。降解速率随着RBC或颗粒浓度的增加而增加。在有或没有RBC的情况下，天然DRP（源自芦荟）显示出比聚环氧乙烷更耐流动诱导的降解。
