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亚洲和非亚洲女性中经超声诊断的胎儿先天性异常

Fetal congenital anomalies diagnosed by ultrasound in Asian and non-Asian women.

作者信息

Atkinson D E, Amin F, Russell S, D'Souza S W

机构信息

Maternal and Fetal Health Research Group, Clinical and Laboratory Sciences, University of Manchester, UK.

出版信息

J Obstet Gynaecol. 2008 Oct;28(7):678-82. doi: 10.1080/01443610802463710.

Abstract

The incidence of congenital heart defects in Asian children is significantly higher than in non-Asian, however little data are available for other anomalies. The Fetal Management Unit at St Mary's Hospital is a tertiary referral centre for prenatal diagnosis in the north-west region. Using data collected after routine prenatal ultrasonography between 1996-2001, we show that in a defined population there was a significant reduction in the incidence of central nervous system (CNS) anomalies over this period but not in other anomalies. Furthermore, fetal congenital anomalies were diagnosed in a higher proportion of Asian than non-Asian women, with CNS, cardiac, bowel, thoracic and facial anomalies and hydrops being statistically significant. Monitoring local trends in a multiethnic community is essential for appropriate counselling, providing parents with an informed choice and in assessing the effectiveness of interventions.

摘要

亚洲儿童先天性心脏缺陷的发病率显著高于非亚洲儿童,然而关于其他异常情况的数据却很少。圣玛丽医院的胎儿管理单元是西北地区产前诊断的三级转诊中心。利用1996年至2001年间常规产前超声检查后收集的数据,我们发现,在特定人群中,这一时期中枢神经系统(CNS)异常的发病率显著降低,但其他异常情况的发病率并未降低。此外,与非亚洲女性相比,亚洲女性中诊断出胎儿先天性异常的比例更高,其中中枢神经系统、心脏、肠道、胸部和面部异常以及水肿在统计学上具有显著意义。监测多民族社区的当地趋势对于进行适当的咨询、为父母提供明智的选择以及评估干预措施的有效性至关重要。

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