Brødløs Hans Kristian, Bramsen Morten B, Agger Peter, Jensen Henrik, Bjerre Marianne, Ringgaard Steffen, Wierup Per, Nielsen Sten Lyager, Hasenkam J Michael, Smerup Morten
Department of Cardiothoracic & Vascular Surgery T and the Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Denmark.
Scand Cardiovasc J. 2009 Aug;43(4):260-6. doi: 10.1080/14017430802604034.
New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling.
Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI.
All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals.
We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure.
已开发出针对梗死后前间隔心肌运动不能的新型手术治疗方法，但由于缺乏合适的大型动物心力衰竭模型，对其功能模式的评估受到阻碍。我们旨在开发并评估一种与人类兼容的慢性梗死后左心室（LV）重塑模型。
14只体重50公斤的雌性猪在左前降支第一对角支远端接受基于导管的冠状动脉闭塞（1小时）。8只体重和年龄匹配的健康动物作为对照。6周后用心血管磁共振成像评估左心室几何形状和功能。
所有动物均从干预中恢复。3只动物在随访期间死亡。所有干预动物均有前间隔运动不能性梗死（平均占左心室心肌的26.5%）。干预动物的舒张末期和收缩末期容积显著增加，而每搏量、射血分数和心输出量降低。详细的功能分析显示干预动物存在显著的收缩和舒张功能障碍。
我们建立了一种可行的梗死后左心室重塑模型，该模型准确模拟了人类发病机制和病理生理学。该模型可能适用于评估心力衰竭的新型手术缓解方法。
