吡那地尔抑制兰尼碱敏感外向电流，格列本脲可拮抗其对兔门静脉细胞的作用。
Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein.
作者信息
Xiong Z L, Kajioka S, Sakai T, Kitamura K, Kuriyama H
机构信息
Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Br J Pharmacol. 1991 Apr;102(4):788-90. doi: 10.1111/j.1476-5381.1991.tb12252.x.
Abstract
Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.
摘要
吡那地尔是一种钾通道开放剂，它抑制了由细胞内储存释放的钙所诱导的对ryanodine敏感的振荡性外向钾电流。格列本脲是一种ATP敏感性钾通道阻滞剂，它可阻止吡那地尔的作用，这表明吡那地尔的血管舒张作用存在一个（除钾通道外的）额外作用位点，格列本脲可作为该位点的拮抗剂发挥作用。
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