Herndon R M, Price D L, Weiner L P
Science. 1977 Feb 18;195(4279):693-4. doi: 10.1126/science.190678.
Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.
小鼠感染小鼠肝炎病毒JHM株会因少突胶质细胞的溶细胞性感染而导致脱髓鞘。在恢复过程中，动物会出现髓鞘再生，这可能是由于存活的少突胶质细胞扩大其区域，或者是新的少突胶质细胞生成所致。用3H标记的胸腺嘧啶核苷进行的电子显微镜放射自显影研究表明，与髓鞘再生相关的细胞是新生成的少突胶质细胞。
