Hovanec J W, Broomfield C A, Steinberg G M, Lanks K W, Lieske C N
Biochim Biophys Acta. 1977 Aug 11;483(2):312-9. doi: 10.1016/0005-2744(77)90059-6.
The first kinetic studies on the spontaneous reactivation of Sarin-inhibited acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are reported. With increasing pH the extent of reactivation increases while the observed rate constant decreases. An analysis of the change in aging rate constant as a function of pH suggests that the aging of alkyl-alkoxy phosphonylated acetylcholinesterases is not solely acid catalyzed.
首次报道了关于沙林抑制的乙酰胆碱酯酶（乙酰胆碱水解酶，EC 3.1.1.7）自发重新激活的动力学研究。随着pH值升高，重新激活的程度增加，而观察到的速率常数降低。对老化速率常数随pH值变化的分析表明，烷基烷氧基膦酰化乙酰胆碱酯酶的老化并非仅由酸催化。
