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1
A new form of specific targeting cancer immunotherapy using anti-tumor monoclonal antibody-conjugated lymphokine-activated killer cells.一种使用抗肿瘤单克隆抗体偶联的淋巴因子激活的杀伤细胞的新型特异性靶向癌症免疫疗法。
Jpn J Cancer Res. 1991 Jun;82(6):621-3. doi: 10.1111/j.1349-7006.1991.tb01895.x.
2
Increased lysis of melanoma by in vivo-elicited human lymphokine-activated killer cells after addition of antiganglioside antibodies in vitro.体外添加抗神经节苷脂抗体后，体内诱导的人淋巴因子激活的杀伤细胞对黑色素瘤的裂解作用增强。
Cancer Res. 1990 Oct 1;50(19):6311-5.
3
HER2-specific cytotoxic activity of lymphokine-activated killer cells in the presence of trastuzumab.在曲妥珠单抗存在的情况下，淋巴因子激活的杀伤细胞的HER2特异性细胞毒性活性。
Anticancer Res. 2005 Mar-Apr;25(2A):827-32.
4
Tumor growth suppression by a mouse/human chimeric anti-CEA antibody and lymphokine-activated killer cells in vitro and in SCID mouse xenograft model.小鼠/人嵌合抗癌胚抗原抗体及淋巴因子激活的杀伤细胞在体外和SCID小鼠异种移植模型中对肿瘤生长的抑制作用
Anticancer Res. 1998 Jan-Feb;18(1A):17-24.
5
Enhanced antitumor activity of a combination treatment with a mouse/human chimeric anti-MK-1 antibody and lymphokine-activated killer cells in vitro and in a severe combined immunodeficient mouse xenograft model.在体外以及严重联合免疫缺陷小鼠异种移植模型中，小鼠/人嵌合抗MK-1抗体与淋巴因子激活的杀伤细胞联合治疗增强抗肿瘤活性。
Cancer Immunol Immunother. 1999 Jul;48(4):165-71. doi: 10.1007/s002620050561.
6
[The anti-pancreatic cancer efficacy of LAK cells mediated by YPC3 monoclonal antibody in vitro and in vivo].YPC3单克隆抗体介导的LAK细胞在体外和体内的抗胰腺癌疗效
Zhonghua Zhong Liu Za Zhi. 1994 Sep;16(5):353-5.
7
MUC1-specific targeting immunotherapy with bispecific antibodies: inhibition of xenografted human bile duct carcinoma growth.双特异性抗体介导的MUC1特异性靶向免疫疗法：对异种移植人胆管癌生长的抑制作用
Cancer Res. 1996 Sep 15;56(18):4205-12.
8
Natural killer and lymphokine-activated killer activities in stomach cancer patients with special emphasis on the effect of 5-fluorouracil, adriamycin and mitomycin-C chemotherapy.胃癌患者的自然杀伤细胞和淋巴因子激活的杀伤细胞活性，特别强调5-氟尿嘧啶、阿霉素和丝裂霉素-C化疗的效果。
Jpn J Clin Oncol. 1990 Mar;20(1):87-93.
9
Cytolytic activity of natural killer cells and lymphokine activated killer cells against hepatitis A virus infected fibroblasts.自然杀伤细胞和淋巴因子激活的杀伤细胞对甲型肝炎病毒感染的成纤维细胞的细胞溶解活性。
J Clin Lab Immunol. 1993;40(2):47-60.
10
[Induction of cytotoxicity from human lymphocytes coated with bispecific antibody against human glioma cells].[抗人胶质瘤细胞双特异性抗体包被的人淋巴细胞诱导细胞毒性作用]
No Shinkei Geka. 1990 Nov;18(11):1001-6.

引用本文的文献

1
JAK2 inhibitor combined with DC-activated AFP-specific T-cells enhances antitumor function in a Fas/FasL signal-independent pathway.JAK2抑制剂与树突状细胞激活的甲胎蛋白特异性T细胞联合使用可通过非Fas/FasL信号通路增强抗肿瘤功能。
Onco Targets Ther. 2016 Jul 20;9:4425-33. doi: 10.2147/OTT.S97941. eCollection 2016.

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Comparison of seven cell lines derived from human gastric carcinomas.源自人胃癌的七种细胞系的比较。
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Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies.通过将抗T3与抗靶细胞抗体交联形成的异聚体对人外周血T细胞进行特异性靶向。
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Specific lysis of human tumor cells by T cells coated with anti-T3 cross-linked to anti-tumor antibody.用与抗肿瘤抗体交联的抗T3包被的T细胞对人肿瘤细胞进行特异性裂解。
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Bispecific F (ab')2 monomer prepared with anti-CD3 and anti-tumor monoclonal antibodies is most potent in induction of cytolysis of human T cells.用抗CD3和抗肿瘤单克隆抗体制备的双特异性F(ab')2单体在诱导人T细胞细胞溶解方面最有效。
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一种使用抗肿瘤单克隆抗体偶联的淋巴因子激活的杀伤细胞的新型特异性靶向癌症免疫疗法。

A new form of specific targeting cancer immunotherapy using anti-tumor monoclonal antibody-conjugated lymphokine-activated killer cells.

作者信息

Shiraiwa H, Sekine T, Tobisu K, Kakizoe T, Koiso K

机构信息

National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo.

出版信息

Jpn J Cancer Res. 1991 Jun;82(6):621-3. doi: 10.1111/j.1349-7006.1991.tb01895.x.

DOI:10.1111/j.1349-7006.1991.tb01895.x
PMID:1906847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918496/
Abstract

Cross-linking of effector T cells to target cancer cells augments their tumor lytic activities. Here we describe a new method of conjugating lymphokine-activated killer (LAK) cells with cancer-specific monoclonal antibody. The LAK cells were biotinylated, treated with avidin, and conjugated with biotinylated monoclonal antibody. These monoclonal antibody-conjugated LAK cells showed specifically enhanced killing activities against anti-tumor antibody-reactive cancer cells, and cold target cells specifically inhibited their activities.

摘要

效应T细胞与靶癌细胞的交联增强了它们的肿瘤溶解活性。在此，我们描述了一种将淋巴因子激活的杀伤（LAK）细胞与癌症特异性单克隆抗体偶联的新方法。将LAK细胞进行生物素化处理，用抗生物素蛋白处理，然后与生物素化的单克隆抗体偶联。这些单克隆抗体偶联的LAK细胞对抗肿瘤抗体反应性癌细胞的杀伤活性有特异性增强，冷靶细胞可特异性抑制其活性。