某些1-[4-(2-二乙氨基乙氧基)苯基羰基]-3,5-双(亚苄基)-4-哌啶酮甲碘化物及相关化合物对大鼠肝线粒体呼吸作用和肿胀的影响
The effect of some 1-[4-(2-diethylaminoethoxy)phenylcarbonyl]-3,5-bis (benzylidene)-4-piperidone methiodides and related compounds on respiration and swelling of rat liver mitochondria.
作者信息
Das S, Das U, Bandy B, Gorecki D K J, Dimmock J R
机构信息
College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada.
出版信息
Pharmazie. 2008 Nov;63(11):827-9.
Abstract
The effect of a number of N-aroyl-3,5-bis(benzylidene)-4-piperidones 2 and related quaternary ammonium compounds 3 on the rates of respiration in rat liver mitochondria were determined. All of the compounds stimulated respiration and the greatest effect was displayed by the compounds in series 3 which caused swelling of mitochondria.
摘要
测定了一系列N-芳酰基-3,5-双（亚苄基）-4-哌啶酮2及相关季铵化合物3对大鼠肝线粒体呼吸速率的影响。所有化合物均刺激呼吸，其中系列3中的化合物产生的影响最大，这些化合物会导致线粒体肿胀。
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