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[胰腺头部浆液性微囊性腺瘤致梗阻性黄疸]

[Serous microcystic adenoma of the head of the pancreas causing an obstructive jaundice].

作者信息

Colović Radoje, Grubor Nikica, Micev Marjan, Ranković Vitomir, Matić Slavko, Latincić Stojan

机构信息

Klinicki centar Srbije, Institut za bolesti digestivnog sistema, Beograd, Srbija.

出版信息

Vojnosanit Pregl. 2008 Nov;65(11):839-42. doi: 10.2298/vsp0811839c.

Abstract

BACKGROUND

Serous microcystic adenoma is a rare benign tumor of the exocrine pancreas originating from the ductal system and composed of a large number of small cysts covered by cuboid cells, filled with clear serous fluid and separated with fibrocolagenous stroma. Most frequently it appears in women in 7th and 8th decades, in the distal pancreas. It shows a very low malignant potential. In 2/3 of patients symptoms are uncharacteristic and in 1/3 they are absent When localised within the head of the pancreas it rarely causes an obstructive jaundice.

CASE REPORT

We presented a 61-year-old female patient who for months had had mild and nonspecific abdominal symptoms developing to progressive obstructive jaundice. At surgery we revealed a rather large policystic mass of the head of the pancreas causing not only obstructive jaundice but also a venous stasis by compression and dislocation of the portomesenteric vein. The tumor was removed with pylorus preserving cephalic duodenopancreatectomy (Whipple's procedure modified by Longmire-Traverso). Histology confirmed serous microcystic adenoma of the pancreas. The postoperative recovery was uneventful and preoperative symptoms disappeared.

CONCLUSION

Although very rare, serous microcystic adenoma might appear within the head of the pancreas and has to be taken into consideration in differential diagnosis of cystic lesions of the head of the pancreas. Very rarely the tumour might cause obstructive jaundice. Surgical resection, which might be demanding, leads to complete recovery.

摘要

背景

浆液性微囊性腺瘤是一种罕见的胰腺外分泌腺良性肿瘤,起源于导管系统,由大量被立方体细胞覆盖的小囊肿组成,囊内充满清亮的浆液,被纤维胶原性间质分隔。它最常出现在70和80岁的女性中,位于胰腺远端。其恶性潜能极低。2/3的患者症状不典型,1/3的患者无症状。当肿瘤位于胰头时,很少引起梗阻性黄疸。

病例报告

我们介绍了一名61岁的女性患者,她数月来一直有轻微的非特异性腹部症状,逐渐发展为进行性梗阻性黄疸。手术中我们发现胰头有一个相当大的多囊性肿块,不仅导致梗阻性黄疸,还因压迫和移位肠系膜上静脉导致静脉淤滞。通过保留幽门的胰头十二指肠切除术(Longmire-Traverso改良的Whipple手术)切除了肿瘤。组织学证实为胰腺浆液性微囊性腺瘤。术后恢复顺利,术前症状消失。

结论

尽管浆液性微囊性腺瘤非常罕见,但可能出现在胰头,在胰腺头部囊性病变的鉴别诊断中必须予以考虑。该肿瘤极少引起梗阻性黄疸。手术切除可能具有挑战性,但可实现完全康复。

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