Okumura T, Uehara A, Kitamori S, Okamura K, Takasugi Y, Namiki M
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Neurosci Lett. 1991 Apr 15;125(1):31-3. doi: 10.1016/0304-3940(91)90123-b.
We have recently found that interleukin-1 (IL-1) acts in the central nervous system to potently inhibit gastric acid and pepsin secretion in rats. In the present study, we examined the effects of IL-1 on the development of gastric mucosal lesions induced by intracisternal (i.c.) thyrotropin-releasing hormone (TRH), a neuropeptide known to centrally stimulate gastric secretion. Pretreatment with i.c. injected IL-1 (10 ng/rat) significantly suppressed the severity of TRH-induced gastric erosions. On the other hand, the same dose of i.c. injected IL-1 failed to exert a cytoprotective action for the gastric mucosa against orally administered absolute ethanol. These results suggest that IL-1 has an anti-ulcer effect mainly through its inhibitory action on gastric secretion.
我们最近发现，白细胞介素-1（IL-1）在中枢神经系统中发挥作用，可有效抑制大鼠胃酸和胃蛋白酶的分泌。在本研究中，我们检测了IL-1对脑池内注射促甲状腺激素释放激素（TRH，一种已知可在中枢刺激胃分泌的神经肽）诱导的胃黏膜损伤发展的影响。脑池内注射IL-1（10 ng/大鼠）预处理可显著减轻TRH诱导的胃糜烂的严重程度。另一方面，相同剂量的脑池内注射IL-1未能对口服无水乙醇的胃黏膜发挥细胞保护作用。这些结果表明，IL-1主要通过其对胃分泌的抑制作用具有抗溃疡作用。
