Xu Yabei, Li Xinyan, Zhou Mingdong
Zensun (Shanghai) Science and Technology Co. Ltd, 328 Bi Bo Road, Zhangjiang Hi-tech Park, Shanghai, PR China.
Curr Opin Pharmacol. 2009 Apr;9(2):214-9. doi: 10.1016/j.coph.2008.11.004. Epub 2008 Dec 11.
Neuregulin-1s are widely expressed signaling molecules that are involved in cell differentiation, proliferation, growth, survival, and apoptosis. They transmit their signals by interacting with cell membrane receptors of the ErbB family, resulting in the activation of intracellular signaling cascades, which participate in various physiological and etiological processes. Besides their essential function in the development of the heart and the physiology of cardiac pumping, there is emerging evidence for the involvement of neuregulin-1/ErbB signals in human disease, including heart failure. These reasons prompt the development of new therapeutic agents based on neuregulin-1.
神经调节蛋白-1是广泛表达的信号分子，参与细胞分化、增殖、生长、存活和凋亡。它们通过与ErbB家族的细胞膜受体相互作用来传递信号，从而激活细胞内信号级联反应，这些反应参与各种生理和病因学过程。除了在心脏发育和心脏泵血生理过程中的重要作用外，越来越多的证据表明神经调节蛋白-1/ErbB信号参与人类疾病，包括心力衰竭。这些原因促使人们开发基于神经调节蛋白-1的新型治疗药物。
