用于外消旋α-（N-苯甲酰基-N-甲基氨基）苯丙酮不对称氢化的聚合物固定化催化剂。
Polymer-immobilized catalyst for asymmetric hydrogenation of racemic alpha-(N-benzoyl-N-methylamino)propiophenone.
作者信息
Chiwara Vinia Ipai, Haraguchi Naoki, Itsuno Shinichi
机构信息
Department of Materials Science, Toyohashi University of Technology, Tempaku-cho, Toyohashi 441-8580, Japan.
出版信息
J Org Chem. 2009 Feb 6;74(3):1391-3. doi: 10.1021/jo802339t.
PMID:19072091
Abstract
Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.
摘要
通过动态动力学拆分实现α-（N-苯甲酰基-N-甲基氨基）苯丙酮的不对称氢化反应，采用聚合物负载的手性二胺-钌-BINAP-叔丁醇钾体系，以几乎完美的对映选择性专一性生成顺式-β-酰胺醇。
Zotero 插件