关于巴西内酯的全合成：C1-C19多元醇片段的立体控制组装。
Toward the total synthesis of the brasilinolides: stereocontrolled assembly of a C1-C19 polyol segment.
作者信息
Paterson Ian, Mühlthau Friedrich A, Cordier Christopher J, Housden Michael P, Burton Paul M, Loiseleur Olivier
机构信息
University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.
出版信息
Org Lett. 2009 Jan 15;11(2):353-6. doi: 10.1021/ol802562b.
PMID:19072327
Abstract
Two highly convergent syntheses of a fully protected C1-C19 polyol subunit of the brasilinolide family of immunosuppressive macrolides are described, exploiting boron-mediated 1,5-anti aldol couplings to form the C8-C9 and C13-C14 bonds.
摘要
本文描述了两种高度收敛的全保护免疫抑制大环内酯类巴西内酯家族C1-C19多元醇亚基的合成方法，利用硼介导的1,5-反式羟醛缩合反应形成C8-C9和C13-C14键。
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