向着阿普隆霉素 A 的第二代合成迈进：通过不对称 Nozaki-Hiyama-Kishi 偶联反应实现 C1-C19 片段的立体选择性组装。
Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling.
机构信息
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan.
出版信息
Org Lett. 2011 Mar 4;13(5):900-3. doi: 10.1021/ol1029657. Epub 2011 Jan 26.
PMID:21268638
Abstract
An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.
摘要
描述了阿朴隆碱 A 的 C1-C19 片段的有效合成。通过不对称的 Nozaki-Hiyama-Kishi 偶联反应，立体选择性地构建了 C14-C15（E）-三取代双键和 C13 立体中心。
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