Nordenstedt Helena, Lagergren Jesper
Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, P9:03, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Expert Rev Gastroenterol Hepatol. 2008 Feb;2(1):93-103. doi: 10.1586/17474124.2.1.93.
Gastroesophageal reflux disease (GERD) is currently one of the most common health problems in the Western world, affecting up to 20% of the adult population weekly and 50% monthly. It generates substantial suffering among patients as well as significant costs to both patients and society in general. GERD can further result in serious complications such as esophageal strictures, Barrett's esophagus and esophageal adenocarcinoma. This review discusses the current knowledge on risk factors and potential protective factors in the development of GERD.
胃食管反流病（GERD）是目前西方世界最常见的健康问题之一，每周影响高达20%的成年人口，每月影响50%。它给患者带来巨大痛苦，也给患者和整个社会造成巨大成本。GERD还可能导致严重并发症，如食管狭窄、巴雷特食管和食管腺癌。本综述讨论了目前关于GERD发生的危险因素和潜在保护因素的知识。
