Luzi Sonija, Morrison Paul D, Powell John, di Forti Marta, Murray Robin M
Institute of Psychiatry, Division of Psychological Medicine, Denmark Hill, London, SE5 8AF, UK.
Neurotox Res. 2008 Oct;14(2-3):105-12. doi: 10.1007/BF03033802.
Cannabis use has increased greatly over the last three decades. The various types of cannabis differ in their concentration of the main psychoactive component, Delta-9-tetrahydrocannabinol (THC), and the other major ingredient, cannabidiol (CBD). Plant engineering has maximized levels of THC, thus increasing the potency of street cannabis. It is well known that cannabis intoxication can cause brief psychotic symptoms like paranoia, whilst recent evidence demonstrates that heavy use of cannabis increases the risk of chronic psychoses like schizophrenia; genetic vulnerability seems to predispose some people to a higher risk. This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis.
在过去三十年里，大麻的使用量大幅增加。不同类型的大麻在其主要精神活性成分Δ-9-四氢大麻酚（THC）和另一种主要成分大麻二酚（CBD）的浓度上存在差异。植物工程技术已将THC的含量最大化，从而提高了街头大麻的效力。众所周知，大麻中毒会引发如偏执狂等短暂的精神病症状，而最近的证据表明，大量使用大麻会增加患如精神分裂症等慢性精神病的风险；遗传易感性似乎使一些人面临更高的风险。本文开始探讨大麻使用增加精神病风险的神经化学机制。
