Ching E P, Poon M C, Neurath D, Ruether B A
Department of Laboratory Medicine, Foothills Provincial General Hospital, Calgary, Alberta, Canada.
Am J Clin Pathol. 1991 Aug;96(2):201-2. doi: 10.1093/ajcp/96.2.201.
Well-known adverse effects of plasma transfusion include viral transmission, allergic complications, and rare anaphylactic reactions. In making clinical decisions to transfuse plasma, a seldom-considered complication is that of red blood cell (RBC) alloimmunization. The authors report a patient in whom strong IgM and IgG anti-E and weak IgG anti-JKa RBC antibodies developed 15 days after infusion of two units of fresh-frozen plasma for volume expansion. These antibodies are potentially hemolytic. This case underscores the importance of considering risks of plasma infusion. Plasma should not be used casually, especially for indications for which alternate therapies, such as crystalloid and colloid solutions, are available.
血浆输注的常见不良反应包括病毒传播、过敏并发症以及罕见的过敏反应。在做出输注血浆的临床决策时，很少被考虑到的一个并发症是红细胞（RBC）同种免疫。作者报告了一名患者，在输注两单位新鲜冷冻血浆以扩容后15天，产生了强效IgM和IgG抗-E以及弱效IgG抗-JKa红细胞抗体。这些抗体可能具有溶血作用。该病例强调了考虑血浆输注风险的重要性。血浆不应被随意使用，尤其是对于有诸如晶体液和胶体液等替代疗法可用的适应症时。
