患有脆性X综合征的幼儿期男孩发育轨迹及预测因素。
Trajectories and predictors of the development of very young boys with fragile X syndrome.
作者信息
Roberts Jane E, Mankowski Jean B, Sideris John, Goldman Barbara Davis, Hatton Deborah D, Mirrett Penny L, Baranek Grace T, Reznick J Steven, Long Anna C J, Bailey Donald B
机构信息
Department of Psychology, University of South Carolina, Barnwell College, Columbia, SC 29208, USA.
出版信息
J Pediatr Psychol. 2009 Sep;34(8):827-36. doi: 10.1093/jpepsy/jsn129. Epub 2008 Dec 12.
OBJECTIVE
To describe the development of young boys with fragile X syndrome (FXS).
METHODS
Fifty-five boys (aged 8-48 months at study entry) with the full mutation FXS received multiple developmental assessments.
RESULTS
As expected, the boys' rate of development was significantly lower than chronological age expectations. No evidence of slowing in the rate of development was found. Autistic behavior was negatively associated with development, but maternal IQ was not. Developmental delays were evident in some domains as early as 9 months; however, initial detection of delays is complicated by measures and criteria used. Developmental age scores at 31 months of age were related to scores obtained at 61 months of age only in the global composite and visual reception domain.
CONCLUSIONS
Developmental delays are evident in some infants with FXS as young as 9 months of age. Pediatric psychologists need to be informed about the developmental profiles in young children with FXS to accurately diagnose, treat, and support these children and their families.
目的
描述脆性X综合征（FXS）男童的发育情况。
方法
55名携带完全突变型FXS的男童（研究开始时年龄为8至48个月）接受了多项发育评估。
结果
正如预期的那样，这些男童的发育速度明显低于按年龄计算的预期水平。未发现发育速度减缓的迹象。自闭症行为与发育呈负相关，但母亲的智商与之无关。早在9个月时，某些领域就出现了发育迟缓；然而，由于所使用的测量方法和标准，延迟的初步检测变得复杂。31个月大时的发育年龄得分仅在整体综合和视觉接受领域与61个月大时获得的得分相关。
结论
早在9个月大的一些FXS婴儿中就明显存在发育迟缓。儿科心理学家需要了解FXS幼儿的发育概况，以便准确诊断、治疗和支持这些儿童及其家庭。
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