Mellado M C, Rodríguez-Contreras R, López R, Fernández-Crehuet M, Bueno A, Gálvez R
Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina de Granada.
Enferm Infecc Microbiol Clin. 1991 Mar;9(3):165-7.
The role of adhesivity as a factor of virulence in cases of N. meningitidis has not yet been established. Unlike other bacteria in which the presence of adhesivity reflects an enhanced virulence, a high capacity of adherence is associated with a low virulence and invasive capacity in cases of meningococcus. In order to gain more insight into the knowledge of this phenomenon we have studied the adhesivity of 109 strains of N. meningitidis to human pharyngeal epithelial cells. Twenty nine out of the 109 strains were isolated from blood or spinal fluid of patients with meningococcal infection (meningitis or septicemia), whereas the remaining 80 strains were obtained from pharyngeal smears of healthy carriers. The adhesivity was measured as the number of meningococci adhered to 50 epithelial cells according to Craven's scale. Strains of healthy carriers showed a greater adhesivity than that of patients (p less than 0.001). The relevance of the pharyngeal area in the evaluation of the adhesive capacity is in accordance with the hypothesis that meningococcal adhesivity decreases when the microorganism crosses the pharyngeal epithelium. The results would support the concept that the virulence of N. meningitidis is related to its adhesiveness.
黏附性作为脑膜炎奈瑟菌致病因素的作用尚未明确。与其他细菌不同，在其他细菌中黏附性的存在反映了毒力增强，而在脑膜炎球菌中，高黏附能力与低毒力和侵袭能力相关。为了更深入了解这一现象，我们研究了109株脑膜炎奈瑟菌对人咽上皮细胞的黏附性。109株菌株中，29株从脑膜炎球菌感染（脑膜炎或败血症）患者的血液或脑脊液中分离得到，其余80株从健康携带者的咽拭子中获得。根据克雷文量表，将黏附性测量为黏附在50个上皮细胞上的脑膜炎球菌数量。健康携带者的菌株显示出比患者更高的黏附性（p小于0.001）。咽部区域在评估黏附能力方面的相关性与以下假设一致，即当微生物穿过咽上皮时，脑膜炎球菌的黏附性会降低。这些结果将支持脑膜炎奈瑟菌的毒力与其黏附性相关的概念。
