Conway Barbara R
Medicines Research Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK.
Recent Pat Drug Deliv Formul. 2008;2(1):1-8. doi: 10.2174/187221108783331410.
There are three main routes for delivery of drugs to the eye: topical, systemic and intra-ocular injection. Controlled delivery systems, such as ocular inserts, minitablets and disposable lenses, can be applied to the exterior surface of the eye for treatment of conditions affecting the anterior segment of the eye. Extended residence times following topical application have the potential to improve bioavailability of the administered drug and additionally a range of strategies has been tested to improve penetration including cyclodextrins, liposomes and nanoparticles. The first part of this review will focus on recent patent filings in this area. The second part of the review reports on drug delivery strategies for treatment of diseases of the posterior segment of the eye. The development of therapeutic agents that require repeated, long-term administration is a driver for the development of sustained-release drug delivery systems to result in less frequent dosing and less invasive techniques. This review article focuses on recently patented applications (from March 2004 to present) of drug delivery systems for ocular delivery.
局部给药、全身给药和眼内注射。控释系统，如眼用插入剂、微型片剂和一次性镜片，可应用于眼睛外表面，用于治疗影响眼前节的病症。局部给药后延长停留时间有可能提高给药药物的生物利用度，此外，还测试了一系列提高渗透性的策略，包括环糊精、脂质体和纳米颗粒。本综述的第一部分将重点关注该领域最近的专利申请。综述的第二部分报告了治疗眼后节疾病的药物输送策略。需要重复、长期给药的治疗药物的开发推动了缓释药物输送系统的发展，以减少给药频率并采用侵入性较小的技术。本文综述重点关注眼用药物输送系统最近的专利申请（从2004年3月至今）。
