兽医学局部应用的控释给药方面。
Aspects in controlled drug delivery for topical applications in veterinary medicine.
作者信息
Lavy Eran, Kirmayer David, Nudelman Zakhar, Orenshtein-Vilensky Liya, Rowan Timothy G, Shenderovich-Gefter Julia, Friedman Michael
机构信息
The Robert H. Smith Faculty of Agriculture, Food and Environment, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O.B. 12, Rehovot 76100, Israel.
Department of Pharmaceutics, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel.
出版信息
Vet Anim Sci. 2022 Feb 2;15:100235. doi: 10.1016/j.vas.2022.100235. eCollection 2022 Mar.
The controlled release of drugs is an appealing area of research as it provides numerous benefits in veterinary and human medicine. In this paper we attempt to analyze certain aspects related to topical drug delivery systems, their successes and failures, and their place in veterinary medicine. Some emphasis is given to the pharmaceutical aspects of the delivery systems, where the material available made it possible. Purely topical devices, such as cattle ear tags and various collars, as well as some topically administered bioavailable delivery systems are discussed. Special attention is given to hitherto under-evaluated delivery systems, such as topical varnishes. A carefully selected bibliography aims to lead the reader easily to the facts, without providing overwhelming data of varying quality. We believe that the paper may be of interest to practicing veterinarians as well as to pharmaceutical scientists working or considering practice in the area.
药物控释是一个具有吸引力的研究领域，因为它在兽医学和人类医学中带来诸多益处。在本文中，我们试图分析与局部给药系统相关的某些方面、它们的成功与失败之处，以及它们在兽医学中的地位。在可行的情况下，会对给药系统的药学方面给予一些强调。讨论了纯局部应用的装置，如牛耳标和各种项圈，以及一些局部给药的生物可利用给药系统。特别关注了迄今评估不足的给药系统，如局部用清漆。精心挑选的参考文献旨在引导读者轻松了解事实，而不提供大量质量参差不齐的数据。我们认为，本文可能会引起执业兽医以及在该领域工作或考虑从业的药物科学家的兴趣。
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