Schulze Rafael, Meehan Ken J, Lopez Antonia, Sweeney Kasina, Winstanley Doug, Apruzzese William, Victor Ross E
Dermatology Department, Naval Medical Center San Diego, San Diego, California, USA.
Dermatol Surg. 2009 Jan;35(1):98-107. doi: 10.1111/j.1524-4725.2008.34388.x. Epub 2008 Dec 8.
To evaluate the efficacy of a 1,064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) laser using lower than traditional fluences (22-40 J/cm(2)) for treatment of pseudofolliculitis barbae (PFB).
Twenty-two patients with PFB refractory to conservative therapy received five weekly treatments over the anterior neck using a 1,064-nm Nd:YAG laser at 12 J/cm(2). Pulse duration was 20 ms with 10 mm spot size. Topical anesthesia was not used. Treatments were completed 15 minutes after patient arrival. Patients presented for 2- and 4-week follow-up. Ten evaluators used a Global Assessment Scale (GAS) to assess dyspigmentation, papule counts, and cobblestoning by comparing baseline to 4-week follow-up visit photographs. Hair and papule counts were performed on five patients and compared with the GAS. Investigators recorded adverse effects using a visual analog and side effects scale.
Eleven patients demonstrated 83% improvement on the GAS (p<.01). There was a mean reduction of 59.5% in dyspigmentation (p<.03), 91.2% in papule count (p<.01), and 75.6% in cobblestoning (p<.02). Patients reported 1 out of 10 on both adverse effects scales.
Low-fluence 1,064-nm laser treatment achieved significant temporary reduction in PFB. Subjects noted minimal pain without topical anesthesia.
评估使用低于传统能量密度(22 - 40 J/cm²)的1064纳米掺钕钇铝石榴石(Nd:YAG)激光治疗须疮样毛囊炎(PFB)的疗效。
22例对保守治疗无效的PFB患者,在前颈部每周接受5次12 J/cm²的1064纳米Nd:YAG激光治疗。脉冲持续时间为20毫秒,光斑大小为10毫米。未使用局部麻醉。患者到达后15分钟完成治疗。患者分别在2周和4周进行随访。10名评估人员使用整体评估量表(GAS),通过比较基线与4周随访时的照片来评估色素沉着、丘疹数量和鹅卵石样改变。对5名患者进行毛发和丘疹计数,并与GAS结果进行比较。研究人员使用视觉模拟和副作用量表记录不良反应。
11例患者在GAS上显示改善83%(p<0.01)。色素沉着平均减少59.5%(p<0.03),丘疹数量减少91.2%(p<0.01),鹅卵石样改变减少75.6%(p<0.02)。患者在两个不良反应量表上的评分均为1/10。
低能量密度的1064纳米激光治疗可使PFB显著暂时减轻。受试者在未使用局部麻醉的情况下表示疼痛轻微。