Smith Robin A J, Adlam Victoria J, Blaikie Frances H, Manas Abdul-Rahman B, Porteous Carolyn M, James Andrew M, Ross Meredith F, Logan Angela, Cochemé Helena M, Trnka Jan, Prime Tracy A, Abakumova Irina, Jones Bruce A, Filipovska Aleksandra, Murphy Michael P
Department of Chemistry, University of Otago, Dunedin, New Zealand.
Ann N Y Acad Sci. 2008 Dec;1147:105-11. doi: 10.1196/annals.1427.003.
Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These compounds contain antioxidant moieties, such as ubiquinone, tocopherol, or nitroxide, that are targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondrial membrane potential, the cations are accumulated within the mitochondria inside cells. There, the conjugated antioxidant moiety protects mitochondria from oxidative damage. Here, we outline some of the work done to date on these compounds and how they may be developed as therapies.
线粒体氧化损伤被认为与多种人类疾病有关；因此，开发减少这种损伤的方法可能具有治疗潜力。已经开发出了靶向线粒体的抗氧化剂，它们能选择性地阻断线粒体氧化损伤并防止某些类型的细胞死亡。这些化合物含有抗氧化基团，如泛醌、生育酚或氮氧化物，它们通过与亲脂性三苯基鏻阳离子共价连接而靶向线粒体。由于线粒体膜电位较大，阳离子会在细胞内的线粒体内积累。在那里，共轭抗氧化基团保护线粒体免受氧化损伤。在此，我们概述了迄今为止在这些化合物上所做的一些工作以及它们如何被开发成治疗方法。
