Horgan R P, Clancy O H, Myers J E, Baker P N
The Maternal and Fetal Health Research Centre, The University of Manchester, St Mary's Hospital, Whitworth Park, Manchester, UK.
BJOG. 2009 Jan;116(2):173-81. doi: 10.1111/j.1471-0528.2008.01997.x.
'Omic' technologies represent a strategy towards high-throughput, simultaneous analysis of thousands of biological molecules. Their development has been accelerated in the post-genomic era since these molecules represent the interaction of genes and environment or the 'functional genome'. Omic domains are of particular interest in the search for predictive disease biomarkers and have additional relevance in understanding pathophysiology and the development of molecularly targeted therapeutics. This review examines the fields of proteomics and metabolomics in the context of obstetrics and gynaecology, including a discussion of methodology, challenges, potential applications and current research.
“组学”技术代表了一种对数千种生物分子进行高通量、同步分析的策略。自后基因组时代以来，这些分子代表了基因与环境的相互作用或“功能基因组”，其发展加速。组学领域在寻找预测性疾病生物标志物方面尤为重要，在理解病理生理学和分子靶向治疗的发展中也具有额外的相关性。本综述在妇产科学背景下审视蛋白质组学和代谢组学领域，包括对方法、挑战、潜在应用和当前研究的讨论。
