Wyatt J S, Edwards A D, Cope M, Delpy D T, McCormick D C, Potter A, Reynolds E O
Department of Paediatrics, University College, London, England.
Pediatr Res. 1991 Jun;29(6):553-7. doi: 10.1203/00006450-199106010-00007.
The response of cerebral blood volume (CBVR) to a small induced change in arterial carbon dioxide tension was studied by near-infrared spectroscopy in 17 newborn infants born from 26 wk of gestation to term. All 17 infants were undergoing mechanical ventilation but had apparently normal brains. The CBVR per kPa change in arterial carbon dioxide tension within the range 3.9 to 9.6 kPa was calculated from the change in total cerebral Hb concentration ([TCHb]) using the equation: delta CBV = delta [TCHb] x 0.89/[H] where [H] is the large vessel Hb concentration. A least-squares regression line with 95% confidence limits was derived for CBVR against gestational age. A highly significant linear increase in CBVR was found: mean CBVR from the regression increased from 0.07 mL.100 g-1.kPa-1 at 26 wk to 0.51 mL.100 g-1.kPa-1 at 40 wk.
采用近红外光谱法研究了17例孕26周出生至足月的新生儿脑血容量（CBVR）对动脉二氧化碳分压小幅度诱导变化的反应。这17例婴儿均接受机械通气，但脑部外观正常。根据总脑血红蛋白浓度（[TCHb]）的变化，使用公式：ΔCBV = Δ[TCHb]×0.89/[H]（其中[H]为大血管血红蛋白浓度）计算动脉二氧化碳分压在3.9至9.6 kPa范围内每kPa变化时的CBVR。得出CBVR与胎龄的最小二乘回归线及其95%置信区间。发现CBVR呈极显著线性增加：回归得出的平均CBVR从孕26周时的0.07 mL·100 g⁻¹·kPa⁻¹增加至40周时的0.51 mL·100 g⁻¹·kPa⁻¹。
