Komlosi Peter, Bell Phillip D, Zhang Zhi-Ren
Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Curr Opin Nephrol Hypertens. 2009 Jan;18(1):57-62. doi: 10.1097/MNH.0b013e32831daf54.
To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature.
In addition to the classical contact site between the macula densa plaque and the afferent arteriole, there is accumulating evidence suggesting a functional association between the distal nephron and the vasculature at three distinct additional sites: at the terminal cortical thick ascending limb, at the early distal tubule and also at the connecting tubule segment. The epithelial cells around the macula densa also sense and respond to changes in tubular flow and salt content and may transmit this signal to the adjacent afferent arteriole.
There are multiple sites of anatomical and functional contact between the distal nephron and the vasculature supplying the glomerulus, and these may contribute to the regulation of glomerular filtration rate and renal hemodynamics.
总结近期有关致密斑以外的远端肾单位节段在感知肾小管环境并将该信号传递至相邻血管系统方面作用的证据。
除了致密斑板块与入球小动脉之间的经典接触部位外，越来越多的证据表明，在另外三个不同部位，远端肾单位与血管系统之间存在功能关联：终末皮质厚升支、早期远端小管以及连接小管节段。致密斑周围的上皮细胞也能感知并响应肾小管液流和盐含量的变化，并可能将该信号传递至相邻的入球小动脉。
远端肾单位与供应肾小球的血管系统之间存在多个解剖学和功能接触部位，这些部位可能有助于调节肾小球滤过率和肾血流动力学。
