Jarek M J, Finger D R, Gillil W R, Giandoni M B
Rheumatology Service (M.J.J., D.R.F.) and Dermatology Service (M.B.G.), Department of Medicine, William Beaumont Army Medical Center, EI Paso, Texas and the Rheumatology Service (W.R.G.), Department of Medicine, Walter Reed Army Medical Center, Washington, District of Columbia.
J Clin Rheumatol. 1996 Jun;2(3):156-9. doi: 10.1097/00124743-199606000-00009.
There are many cutaneous findings that have been described in systemic lupus erythematosus (SLE). These include disease-specific and nonspecific lesions. Periorbital edema in the absence of proteinuria or hypoalbuminemia has been only rarely described. We report three patients who developed marked periorbital edema in association with a flare of SLE. All patients were without proteinuria or significant hypoalbuminemia, and no other etiology for the periorbital swelling was identified. This occurred despite all three taking antimalarial therapy, but the edema resolved promptly and completely with glucocorticoids. One of these patients also had transverse leukonychia, or Mees' lines, present on several fingernails, that appeared to correspond with previous SLE flares.Mees' lines and periorbital edema may represent two additional nonspecific but disease-related dermatologic manifestations of SLE. Whereas periorbital edema usually develops in concert with other clinical evidence of a lupus flare and is easily treated, Mees' lines appear to serve as a time line for previous SLE activity.
系统性红斑狼疮（SLE）有许多已被描述的皮肤表现。这些包括疾病特异性和非特异性病变。在无蛋白尿或低白蛋白血症的情况下出现眶周水肿的情况仅有很少的描述。我们报告了3例与SLE病情活动相关而出现明显眶周水肿的患者。所有患者均无蛋白尿或显著低白蛋白血症，且未发现眶周肿胀的其他病因。尽管这3例患者均接受抗疟治疗，但眶周水肿在使用糖皮质激素后迅速且完全消退。其中1例患者的几个指甲上还出现了横行白甲，即梅氏线，这似乎与既往的SLE病情活动相对应。梅氏线和眶周水肿可能代表SLE另外两种非特异性但与疾病相关的皮肤表现。眶周水肿通常与狼疮病情活动的其他临床证据同时出现且易于治疗，而梅氏线似乎可作为既往SLE活动的时间线。
