Rahim Fazal, Gupta Devanshi, Bertorini Tulio E, Ledoux Mark S
From the Department of Neurology, University of Tennessee Health Science Center Memphis.
J Clin Neuromuscul Dis. 2003 Dec;5(2):108-14. doi: 10.1097/00131402-200312000-00007.
Dropped head secondary to weakness of the neck extensors has been reported in a wide assortment of neuromuscular disorders. Infrequently, dropped head can be the first sign of disease. We describe two patients with dropped head as the presenting manifestation of mitochondrial myopathy. In both patients, serum lactate was elevated and muscle biopsy showed mitochondrial proliferation. Mitochondrial myopathy should be considered in the differential diagnosis of dropped head syndrome, particularly when other, more common causes such as myasthenia gravis, polymyositis, and amyotrophic lateral sclerosis have been excluded by appropriate laboratory and electrophysiological studies.
颈部伸肌无力导致的垂头症已在多种神经肌肉疾病中被报道。垂头症作为疾病的首发症状较为罕见。我们描述了两名以垂头症为线粒体肌病首发表现的患者。两名患者的血清乳酸均升高，肌肉活检显示线粒体增殖。在垂头综合征的鉴别诊断中应考虑线粒体肌病，尤其是在通过适当的实验室和电生理研究排除了其他更常见的病因，如重症肌无力、多发性肌炎和肌萎缩侧索硬化症之后。
