β-氧代链烷腈的研究：3-[2,6-二芳基-4-吡啶基]-3-氧代丙腈的简单新颖合成法
Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles.
作者信息
Riyadh Sayed M, Al-Matar Hamad M, Elnagdi Mohamed H
机构信息
Department of Chemistry, Faculty of Science, Cairo University, Giza-12613- Egypt.
出版信息
Molecules. 2008 Dec 15;13(12):3140-8. doi: 10.3390/molecules13123140.
Abstract
Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel beta-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
摘要
2-氰基-4-氧代-2-(2-氧代-2-芳基乙基)-4-芳基丁酸乙酯3a、b与乙酸铵发生杂芳构化反应生成2,6-二芳基异烟酸乙酯4a、b。用乙腈处理后者得到新型β-氧代链烷腈6a、b。6a、b与苯肼和羟胺反应分别得到相应的吡啶基氨基吡唑8a、b和吡啶基氨基异恶唑10a、b。
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