1-芳基-3（或5）-烷基/芳基-5（或3）-（N-环氨基）吡唑的高区域选择性合成
Highly regioselective synthesis of 1-aryl-3 (or 5)-alkyl/aryl-5 (or 3)-(N-cycloamino)pyrazoles.
作者信息
Peruncheralathan S, Yadav A K, Ila H, Junjappa H
机构信息
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
出版信息
J Org Chem. 2005 Nov 11;70(23):9644-7. doi: 10.1021/jo051478u.
PMID:16268652
Abstract
[Reaction: see text]. An efficient highly regioselective protocol for the synthesis of isomeric 1,3-diaryl (or 1-aryl-3-alkyl) and 1,5-diaryl (or 1-aryl-5-alkyl)-5 (or 3)-(N-cycloamino)pyrazoles has been reported by cyclocondensation of common alpha-oxoketene N,S-acetal precursors with arylhydrazines by variation of reaction conditions.
摘要
[反应：见正文]。通过改变反应条件，利用常见的α-氧代烯酮N，S-乙缩醛前体与芳基肼进行环缩合反应，已报道了一种高效、高区域选择性的合成异构1,3-二芳基（或1-芳基-3-烷基）和1,5-二芳基（或1-芳基-5-烷基）-5（或3）-（N-环氨基）吡唑的方法。
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