Küppers Ralf
Institute of Cell Biology (Tumour Research), University of Duisburg-Essen, Medical School, Virchowstrasse 173, 45122 Essen, Germany.
Nat Rev Cancer. 2009 Jan;9(1):15-27. doi: 10.1038/nrc2542. Epub 2008 Dec 11.
Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent genetic lesions. The pathogenetic role for Epstein-Barr virus infection has also been substantiated. HRS cells in classical Hodgkin's lymphoma have several characteristics that are unusual for lymphoid tumour cells, and the Hodgkin's lymphoma microenvironment is dominated by an extensive mixed, potentially inflammatory cellular infiltrate. Understanding the contribution of all of these changes to the pathogenesis of this disease is essential for the development of novel therapies.
霍奇金淋巴瘤于1832年首次被描述。然而，这种淋巴瘤的病因长期以来一直成谜。直到过去10年，具有诊断意义的霍奇金和里德-斯腾伯格（HRS）细胞的B细胞性质才被揭示出来，同时还发现了几种复发性基因病变。爱泼斯坦-巴尔病毒感染的致病作用也得到了证实。经典霍奇金淋巴瘤中的HRS细胞具有一些淋巴样肿瘤细胞所不具备的特征，并且霍奇金淋巴瘤微环境以广泛的混合性、潜在炎症性细胞浸润为主。了解所有这些变化对该疾病发病机制的作用对于开发新疗法至关重要。
Zotero 插件