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Targeting nicotinic receptor antagonists as novel pharmacotherapies for tobacco dependence and relapse.

作者信息

Dwoskin Linda P, Bardo Michael T

机构信息

University of Kentucky National Cooperative Drug Discovery Group, Lexington, KY, USA.

出版信息

Neuropsychopharmacology. 2009 Jan;34(1):244-6. doi: 10.1038/npp.2008.157.

DOI:10.1038/npp.2008.157
PMID:19079069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3089967/
Abstract
摘要

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本文引用的文献

1
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.在发现治疗烟草依赖的新型药物治疗剂中靶向与奖赏相关的烟碱受体。
Nebr Symp Motiv. 2009;55:31-63. doi: 10.1007/978-0-387-78748-0_4.
2
Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.新型烟碱受体拮抗剂N,N'-十二烷-1,12-二基-双-3-吡啶鎓二溴化物在大鼠体内的药代动力学
Drug Metab Dispos. 2008 Oct;36(10):2024-9. doi: 10.1124/dmd.108.020354. Epub 2008 Jul 10.
3
N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.N,N'-烷二基-双-3-吡啶鎓作为烟碱受体拮抗剂:对尼古丁诱发的多巴胺释放和多动的抑制作用
J Pharmacol Exp Ther. 2008 Aug;326(2):563-76. doi: 10.1124/jpet.108.136630. Epub 2008 May 6.
4
Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.使用慢病毒表达载体在小鼠脑中进行烟碱型乙酰胆碱受体的靶向体内表达。
J Mol Neurosci. 2006;30(1-2):105-6. doi: 10.1385/jmn:30:1:105.
5
The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.新型烟碱受体拮抗剂N,N-十二烷-1,12-二基-双-3-吡啶鎓二溴化物(bPiDDB)对急性和反复尼古丁诱导的大鼠伏隔核细胞外多巴胺增加的影响。
Neuropharmacology. 2007 Mar;52(3):755-63. doi: 10.1016/j.neuropharm.2006.09.012. Epub 2006 Nov 9.
6
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.新型烟碱受体拮抗剂N,N'-十二烷-1,12-二基-双-3-吡啶鎓二溴化物对大鼠尼古丁自我给药及多动的影响
Psychopharmacology (Berl). 2006 Mar;184(3-4):426-34. doi: 10.1007/s00213-005-0163-8. Epub 2005 Oct 12.
7
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.亚型选择性烟碱受体拮抗剂:作为戒烟药物的潜力。
Bioorg Med Chem Lett. 2004 Apr 19;14(8):1863-7. doi: 10.1016/j.bmcl.2003.10.073.