Sivenius J, Kälviäinen R, Ylinen A, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Epilepsia. 1991 Jul-Aug;32(4):539-42. doi: 10.1111/j.1528-1157.1991.tb04689.x.
Forty-three patients completed a double-blind, placebo-controlled study of Gabapentin (GBP) as add-on therapy in partial and secondarily generalized seizures. All patients were followed for an initial 3-month baseline period, after which they were randomly allocated to receive either a placebo or 900 or 1,200 mg/day GBP for 3 months. A statistically significant difference in seizure frequency from the baseline to the treatment phase was noted between patients receiving placebo and GBP 1,200 mg, in whom seizure frequency decreased 57%. The GBP dosage of 900 mg appeared to be ineffective. A close relationship was observed between the serum GBP concentrations and the GBP dosage based on the seizure frequency. Serum GBP concentrations greater than 2 micrograms/ml resulted in a lower frequency of seizures. The adverse effects were minor and consisted mainly of transient drowsiness. GBP appears to be effective in the treatment of partial epileptic seizures in a dosage-related manner.
43名患者完成了一项加巴喷丁（GBP）作为部分性发作和继发性全身性发作附加治疗的双盲、安慰剂对照研究。所有患者在最初的3个月基线期接受随访，之后他们被随机分配接受安慰剂或900或1200毫克/天的GBP治疗3个月。在接受安慰剂和1200毫克GBP的患者中，从基线期到治疗阶段的癫痫发作频率有统计学上的显著差异，其中癫痫发作频率降低了57%。900毫克的GBP剂量似乎无效。基于癫痫发作频率，观察到血清GBP浓度与GBP剂量之间存在密切关系。血清GBP浓度大于2微克/毫升导致癫痫发作频率降低。不良反应轻微，主要包括短暂性嗜睡。GBP似乎以剂量相关的方式有效治疗部分性癫痫发作。
