Promise of mGluR2/3 activators in psychiatry.
作者信息
Conn P Jeffrey, Jones Carrie K
机构信息
Vanderbilt Program in Drug Discovery, Department of Pharmacology, Vanderbilt Medical Center, Nashville, TN, USA.
出版信息
Neuropsychopharmacology. 2009 Jan;34(1):248-9. doi: 10.1038/npp.2008.156.
Abstract
摘要
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本文引用的文献
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.激活代谢型谷氨酸受体2/3作为治疗精神分裂症的新方法：一项随机2期临床试验
Nat Med. 2007 Sep;13(9):1102-7. doi: 10.1038/nm1632. Epub 2007 Sep 2.
2
Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.联苯茚满二酮A，一种亲代谢型谷氨酸受体亚型2的正变构调节剂，在小鼠中具有抗精神病样和抗焦虑样作用。
J Pharmacol Exp Ther. 2006 Jul;318(1):173-85. doi: 10.1124/jpet.106.102046. Epub 2006 Apr 11.
3
A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity.代谢型谷氨酸（mGlu）2受体的选择性变构增强剂在预测抗精神病活性的小鼠模型中具有与正构mGlu2/3受体激动剂相似的作用。
J Pharmacol Exp Ther. 2005 Dec;315(3):1181-7. doi: 10.1124/jpet.105.091074. Epub 2005 Aug 25.
4
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders.代谢型谷氨酸受体作为焦虑和应激障碍的新靶点。
Nat Rev Drug Discov. 2005 Feb;4(2):131-44. doi: 10.1038/nrd1630.
5
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J Med Chem. 2003 Jul 17;46(15):3189-92. doi: 10.1021/jm034015u.
6
Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia?代谢型谷氨酸受体2/3激动剂的临床前药理学：治疗精神分裂症的新型药物？
Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):215-25. doi: 10.2174/1568007024606177.
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