Targeting AMPA and kainate receptors in neurological disease: therapies on the horizon?
作者信息
Swanson Geoffrey T
机构信息
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
出版信息
Neuropsychopharmacology. 2009 Jan;34(1):249-50. doi: 10.1038/npp.2008.158.
Abstract
摘要
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本文引用的文献
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AMPA potentiator treatment of cognitive deficits in Alzheimer disease.α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）增强剂治疗阿尔茨海默病认知缺陷
Neurology. 2007 Mar 27;68(13):1008-12. doi: 10.1212/01.wnl.0000260240.46070.7c.
2
AMPA receptor potentiators as cognitive enhancers.作为认知增强剂的AMPA受体增强剂。
IDrugs. 2007 Mar;10(3):185-92.
3
Talampanel.他拉莫三嗪
Neurotherapeutics. 2007 Jan;4(1):126-9. doi: 10.1016/j.nurt.2006.11.001.
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Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial.AMPA调节化合物CX516对脆性X综合征认知和行为的影响：一项对照试验。
J Child Adolesc Psychopharmacol. 2006 Oct;16(5):525-40. doi: 10.1089/cap.2006.16.525.
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Glutamate-based therapeutic approaches: ampakines.
Curr Opin Pharmacol. 2006 Feb;6(1):82-8. doi: 10.1016/j.coph.2005.09.005. Epub 2005 Dec 19.
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