• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Distal IgA immunity can be sustained by alphaEbeta7+ B cells in L-selectin-/- mice following oral immunization.口服免疫后，L-选择素基因敲除小鼠中的αEβ7⁺ B细胞可维持远端IgA免疫。
Mucosal Immunol. 2008 Jan;1(1):68-77. doi: 10.1038/mi.2007.2.
2
Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues.L-选择素的缺失会延迟非肠道效应组织中的黏膜B细胞反应。
J Immunol. 2002 Nov 15;169(10):5649-59. doi: 10.4049/jimmunol.169.10.5649.
3
Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectin.前沿：黏膜效应B细胞归巢受体依赖性的二分法：α(E)与L-选择素
J Immunol. 2001 Sep 1;167(5):2441-5. doi: 10.4049/jimmunol.167.5.2441.
4
Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin alpha 4 beta 7 to naive and memory phenotypes.人肠道相关淋巴组织中B细胞和T细胞归巢受体的拓扑分布：L-选择素和整合素α4β7与初始和记忆表型的关系
Am J Pathol. 1997 Jan;150(1):187-99.
5
Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.全身、肠道和鼻腔免疫后人类循环抗体形成细胞上组织特异性黏附分子的差异表达。效应B细胞反应分区化的分子基础。
J Clin Invest. 1997 Mar 15;99(6):1281-6. doi: 10.1172/JCI119286.
6
Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant.优化口服疫苗：使用霍乱毒素作为佐剂诱导针对破伤风类毒素的全身和黏膜B细胞及抗体反应。
Infect Immun. 1993 Oct;61(10):4272-9. doi: 10.1128/iai.61.10.4272-4279.1993.
7
Homing commitment of lymphocytes activated in the human gastric and intestinal mucosa.人胃和肠黏膜中活化淋巴细胞的归巢趋向性
Gut. 2001 Oct;49(4):519-25. doi: 10.1136/gut.49.4.519.
8
Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant.用霍乱毒素佐剂进行口服免疫后，在局部以及全身淋巴组织中刺激抗原特异性T细胞和B细胞记忆。
Immunology. 1993 Oct;80(2):197-203.
9
Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector.用沙门氏菌疫苗载体经口免疫的L-选择素缺陷小鼠的黏膜免疫受损。
J Immunol. 2001 Jul 1;167(1):407-15. doi: 10.4049/jimmunol.167.1.407.
10
Nasal vaccination of β7 integrin-deficient mice retains elevated IgA immunity.β7 整合素缺陷型小鼠的鼻腔免疫接种可保留增强的 IgA 免疫。
Immunol Cell Biol. 2020 Sep;98(8):667-681. doi: 10.1111/imcb.12364. Epub 2020 Jul 8.

引用本文的文献

1
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.一种整合素 αEβ7 依赖的 IgA 穿越机制需要浆细胞与肠道上皮的直接接触。
Mucosal Immunol. 2021 Nov;14(6):1347-1357. doi: 10.1038/s41385-021-00439-x. Epub 2021 Aug 20.
2
Nasal vaccination of β7 integrin-deficient mice retains elevated IgA immunity.β7 整合素缺陷型小鼠的鼻腔免疫接种可保留增强的 IgA 免疫。
Immunol Cell Biol. 2020 Sep;98(8):667-681. doi: 10.1111/imcb.12364. Epub 2020 Jul 8.
3
Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells.脂肪组织来源的间充质干细胞对黏膜免疫衰老的恢复作用。
Int Immunol. 2017 Jan 1;29(1):5-10. doi: 10.1093/intimm/dxx001.
4
Involvement of L-selectin expression in Burkholderia pseudomallei-infected monocytes invading the brain during murine melioidosis.L-选择素表达参与伯克霍尔德菌感染的单核细胞在小鼠类鼻疽病中侵入大脑。
Virulence. 2017 Aug 18;8(6):751-766. doi: 10.1080/21505594.2016.1232239. Epub 2016 Sep 19.
5
A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.一种分子黏膜佐剂，可增强老年人对肺炎球菌感染的免疫力。
Immune Netw. 2015 Feb;15(1):9-15. doi: 10.4110/in.2015.15.1.9. Epub 2015 Feb 17.
6
Novel vaccine development strategies for inducing mucosal immunity.诱导黏膜免疫的新型疫苗研发策略。
Expert Rev Vaccines. 2012 Mar;11(3):367-79. doi: 10.1586/erv.11.196.

本文引用的文献

1
Current status of live attenuated influenza virus vaccine in the US.美国减毒活流感病毒疫苗的现状。
Virus Res. 2004 Jul;103(1-2):177-85. doi: 10.1016/j.virusres.2004.02.031.
2
Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells.白细胞介素12和白细胞介素10对超抗原诱导CD8 + T细胞表达皮肤淋巴细胞相关抗原（CLA）和αEβ7整合素（CD103）的不同作用。
Clin Immunol. 2004 Apr;111(1):119-25. doi: 10.1016/j.clim.2004.01.003.
3
Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues.L-选择素的缺失会延迟非肠道效应组织中的黏膜B细胞反应。
J Immunol. 2002 Nov 15;169(10):5649-59. doi: 10.4049/jimmunol.169.10.5649.
4
Mucosal addressin expression and binding-interactions with naive lymphocytes vary among the cranial, oral, and nasal-associated lymphoid tissues.黏膜定居素的表达以及与幼稚淋巴细胞的结合相互作用在颅部、口腔和鼻相关淋巴组织之间存在差异。
Eur J Immunol. 2002 Nov;32(11):3029-39. doi: 10.1002/1521-4141(200211)32:11<3029::AID-IMMU3029>3.0.CO;2-9.
5
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine.在小鼠小肠系膜对侧肠壁上鉴定出多个孤立的淋巴滤泡。
J Immunol. 2002 Jan 1;168(1):57-64. doi: 10.4049/jimmunol.168.1.57.
6
Differential expression of GL7 activation antigen on bone marrow B cell subpopulations and peripheral B cells.骨髓B细胞亚群和外周血B细胞上GL7激活抗原的差异表达。
Immunol Lett. 2001 Sep 3;78(2):89-96. doi: 10.1016/s0165-2478(01)00239-5.
7
Role of integrin alphaE(CD103)beta7 for tissue-specific epidermal localization of CD8+ T lymphocytes.整合素αE（CD103）β7在CD8 + T淋巴细胞组织特异性表皮定位中的作用。
J Invest Dermatol. 2001 Sep;117(3):569-75. doi: 10.1046/j.0022-202x.2001.01481.x.
8
Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectin.前沿：黏膜效应B细胞归巢受体依赖性的二分法：α(E)与L-选择素
J Immunol. 2001 Sep 1;167(5):2441-5. doi: 10.4049/jimmunol.167.5.2441.
9
Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector.用沙门氏菌疫苗载体经口免疫的L-选择素缺陷小鼠的黏膜免疫受损。
J Immunol. 2001 Jul 1;167(1):407-15. doi: 10.4049/jimmunol.167.1.407.
10
Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction.整合素αE（CD103）β7通过一种不依赖E-钙黏蛋白的相互作用介导与肠道微血管内皮细胞系的黏附。
J Immunol. 2001 Mar 1;166(5):3506-14. doi: 10.4049/jimmunol.166.5.3506.

口服免疫后，L-选择素基因敲除小鼠中的αEβ7⁺ B细胞可维持远端IgA免疫。

Distal IgA immunity can be sustained by alphaEbeta7+ B cells in L-selectin-/- mice following oral immunization.

作者信息

Pascual D W, Riccardi C, Csencsits-Smith K

机构信息

Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA.

出版信息

Mucosal Immunol. 2008 Jan;1(1):68-77. doi: 10.1038/mi.2007.2.

DOI:10.1038/mi.2007.2
PMID:19079162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9811399/
Abstract

Understanding the role of homing receptors could aid vaccine strategies for developing distal mucosal immunity. Infection studies have revealed that immune intestinal B cells use alpha(4)beta(7) homing receptors, but their role in subsequent oral immunization with soluble antigens is unknown. To assess the influence of L-selectin and alpha(4)beta(7) on distal B cells following oral cholera toxin (CT) immunization, L-selectin-deficient (L-Sel(-/-)) IgA anti-CT-B-specific B cells were enhanced 30-, 9.2-, and 3.5-fold in head and neck lymph nodes (HNLNs), nasal-associated lymphoid tissue, and nasal passages (NPs), respectively, vs. L-Sel(+/+) mice. Cell-sorted intestinal and NP IgA antibody-forming cells (AFCs) were mostly alpha(4)beta(7)(+), unlike HNLN L-Sel(-/-) IgA and IgG anti-CT-B AFCs that were alpha(E)beta(7)(+), contrasting with L-Sel(+/+) HNLN IgA AFCs that were mostly alpha(4)beta(7)(+). In vitro studies revealed that L-Sel(-/-) HNLN B cells preferentially expressed alpha(E) following polyclonal stimulation. These studies show that HNLN B cells express alpha(E)beta(7) in the absence of L-selectin to sustain distal IgA responses.

摘要

了解归巢受体的作用有助于制定增强远端黏膜免疫的疫苗策略。感染研究表明，免疫肠道B细胞利用α(4)β(7)归巢受体，但它们在随后用可溶性抗原进行口服免疫中的作用尚不清楚。为了评估口服霍乱毒素（CT）免疫后L-选择素和α(4)β(7)对远端B细胞的影响，与L-Sel(+/+)小鼠相比，L-选择素缺陷（L-Sel(-/-)）的IgA抗CT-B特异性B细胞在头颈部淋巴结（HNLN）、鼻相关淋巴组织和鼻道（NP）中分别增强了30倍、9.2倍和3.5倍。细胞分选的肠道和NP IgA抗体形成细胞（AFC）大多为α(4)β(7)(+)，这与HNLN L-Sel(-/-) IgA和IgG抗CT-B AFC不同，后者为α(E)β(7)(+)，与大多为α(4)β(7)(+)的L-Sel(+/+) HNLN IgA AFC形成对比。体外研究表明，L-Sel(-/-) HNLN B细胞在多克隆刺激后优先表达α(E)。这些研究表明，在缺乏L-选择素的情况下，HNLN B细胞表达α(E)β(7)以维持远端IgA反应。