一种分子黏膜佐剂，可增强老年人对肺炎球菌感染的免疫力。
A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.
机构信息
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Immune Netw. 2015 Feb;15(1):9-15. doi: 10.4110/in.2015.15.1.9. Epub 2015 Feb 17.
Abstract
Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.
摘要
肺炎链球菌（肺炎球菌）可引起上呼吸道的严重感染，常导致老年人病重甚至死亡。因此，诱导针对这种病原体的安全有效的黏膜免疫非常重要，以预防肺炎球菌感染。然而，在老年人中诱导保护性黏膜 IgA 抗体应答是一项非常困难的任务。由编码 Flt3 配体 cDNA（pFL）和 CpG 寡核苷酸（CpG ODN）的质粒组成的联合鼻腔佐剂成功增强了老年小鼠的肺炎球菌特异性黏膜免疫。特别是，基于肺炎球菌表面蛋白 A 的鼻内疫苗与 pFL 和 CpG ODN 联合使用可完全预防肺炎球菌感染。这些结果表明，联合 DNA 佐剂的鼻腔给药为保护老年人免受肺炎球菌感染提供了有吸引力的潜力。
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