伴有免疫球蛋白和T细胞受体δ基因重排的慢性粒细胞白血病非淋巴细胞原始细胞危象
Non-lymphoid blast crisis of CML with rearrangement of immunoglobulin and T-cell receptor delta genes.
作者信息
Bashey A, Vulliamy T, Cai B S, Schwarer A P, Goldman J M
机构信息
Department of Haematology, Royal Postgraduate Medical School, London, U.K.
出版信息
Eur J Haematol. 1991 Jul;47(1):36-41. doi: 10.1111/j.1600-0609.1991.tb00558.x.
We report a patient with chronic myeloid leukaemia (Philadelphia-positive with M-BCR rearrangement) in transformation whose blast cells had myelomonocytic morphology, absent terminal deoxynucleotidyl transferase expression and non-lymphoid cell surface markers (CD10-, CD19-, CD33+, CD14+, CD11+). Leukaemia cell DNA showed rearrangement of both immunoglobulin heavy chain and T-cell receptor delta genes. Such rearrangements may be a feature of a small proportion of patients with non-lymphoid transformation of CML as they are in a minority of cases of de novo acute non-lymphoblastic leukaemia.
我们报告了1例慢性髓系白血病（费城染色体阳性伴M-BCR重排）发生转化的患者，其原始细胞具有粒单核细胞形态，无末端脱氧核苷酸转移酶表达，且具有非淋巴细胞表面标志物（CD10阴性、CD19阴性、CD33阳性、CD14阳性、CD11阳性）。白血病细胞DNA显示免疫球蛋白重链和T细胞受体δ基因均发生重排。这种重排可能是一小部分慢性髓系白血病非淋巴细胞转化患者的特征，就如同在少数原发性急性非淋巴细胞白血病病例中一样。
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