Baars E W, Savelkoul H F J
Department of Healthcare and Nutrition, Louis Bolk Instituut, 3972 LA Driebergen, The Netherlands.
Mediators Inflamm. 2008;2008:496467. doi: 10.1155/2008/496467. Epub 2008 Nov 30.
In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in vitro after polyclonal stimulation of T-cells. The differentiation capacity and the influence with regard to Th1 (IFN-gamma) and Th2 (IL-5) cells were examined. Citrus/Cydonia comp. has a selective effect on the differentiation of T-cells by producing relatively more IL-10 than IL-12. By that, it also seems to have an effect on the induction of regulatory (IL-10 producing) T-cell subsets. It is in vitro capable of neutralizing (to some extent) the changes, characteristic to allergic rhinitis, with regard to the maturation, differentiation, and activity of the immune system. Thus, Citrus/Cydonia comp. can potentially restore the disturbed immune state of rhinitis patients, which essentially could be sufficient to make allergic symptoms disappear permanently.
在两项体外研究中，我们分别从健康供体和过敏供体中检测了柑橘/榅桲复合物的免疫（作用途径）效应；从外周血中分离出外周血单核细胞（PBMCs），并在T细胞多克隆刺激后进行体外分析。检测了其分化能力以及对Th1（干扰素-γ）和Th2（白细胞介素-5）细胞的影响。柑橘/榅桲复合物通过产生相对较多的白细胞介素-10而非白细胞介素-12，对T细胞分化具有选择性作用。据此，它似乎也对调节性（产生白细胞介素-10的）T细胞亚群的诱导有影响。它在体外能够（在一定程度上）中和过敏性鼻炎特有的关于免疫系统成熟、分化和活性的变化。因此，柑橘/榅桲复合物有可能恢复鼻炎患者紊乱的免疫状态，这从本质上可能足以使过敏症状永久消失。
