Wang Yuan Min, Hu Min, Wang Ya, Polhill Tania, Zhang Geoff Yu, Wang Yiping, Lee Vincent W S, Harris David C H, Alexander Stephen I
Int J Clin Exp Med. 2008;1(4):294-304. Epub 2008 Aug 20.
Regulatory T cells (Tregs) have a key role in immune homeostasis and in suppressing unwanted inflammatory responses toward self-antigens. Tregs have been implicated in the control of initial activation events, and play roles in limiting proliferation, differentiation and effector functions of T helper cells. However, the activities of Tregs in the development and progression of kidney disease are not fully elucidated. We have demonstrated the potency of Tregs in animal models of kidney disease. In this review, we summarise mechanistic information from rodent models on the roles of Tregs in glomerular immunopathology and discuss the function of Tregs in diverse kidney diseases. Further studies of Tregs should provide important insights into designing of therapeutic strategies to prevent human kidney disease.
调节性T细胞（Tregs）在免疫稳态以及抑制针对自身抗原的不必要炎症反应中起关键作用。Tregs参与了初始激活事件的调控，并在限制辅助性T细胞的增殖、分化和效应功能方面发挥作用。然而，Tregs在肾脏疾病发生发展中的活动尚未完全阐明。我们已经在肾脏疾病动物模型中证明了Tregs的作用。在本综述中，我们总结了来自啮齿动物模型的关于Tregs在肾小球免疫病理学中作用的机制信息，并讨论了Tregs在各种肾脏疾病中的功能。对Tregs的进一步研究应为预防人类肾脏疾病的治疗策略设计提供重要见解。
