Agrawal Anshu, Lourenço Elaine V, Gupta Sudhir, La Cava Antonio
Int J Clin Exp Med. 2008;1(4):305-9. Epub 2008 Aug 12.
Aging associates with an increased pro-inflammatory activity that is commonly associated with oxidative tissue damage. One pro-inflammatory molecule that facilitates oxidative stress is leptin, a hormone that regulates metabolism, endocrine and immune functions. To address whether leptin levels correlated with oxidative stress in aging, we performed cross-sectional measurements of circulating plasma leptin in groups of healthy individuals that were divided by age and gender. It was found that leptin levels were comparable between young (N=54) and elderly humans (N=56) in each gender, and women had higher levels than men, irrespectively of age. Interestingly, oxidative stress measured as total glutathione levels correlated positively with elevated leptin levels in elderly women but not in men or in the groups of younger individuals. The data suggest that a gender bias for leptin that is maintained with age can associate with increased propensity to oxidative stress in the elderly.
衰老与促炎活性增加相关，而促炎活性通常与氧化组织损伤有关。一种促进氧化应激的促炎分子是瘦素，它是一种调节代谢、内分泌和免疫功能的激素。为了探讨瘦素水平是否与衰老过程中的氧化应激相关，我们对按年龄和性别分组的健康个体进行了循环血浆瘦素的横断面测量。结果发现，无论男女，年轻组（N = 54）和老年组（N = 56）的瘦素水平相当，且女性的瘦素水平高于男性，与年龄无关。有趣的是，以总谷胱甘肽水平衡量的氧化应激与老年女性瘦素水平升高呈正相关，而在男性或年轻个体组中则不然。数据表明，随着年龄增长而维持的瘦素性别偏差可能与老年人氧化应激倾向增加有关。
